Efficacy of a long-acting growth hormone (GH) preparation in patients with adult GH deficiency.

摘要: Context: Treatment of adult GH deficiency (AGHD) with daily injections results in decreased adipose mass, increased lean body mass (LBM), bone mineral density, and improved quality life. Objective: This study seeks to determine whether a depot preparation given every 14 d would lead comparable decreases trunk tissue as GH. Design: open-label, randomized compares subjects receiving GH, or no therapy. Setting: The was performed at 23 university local referral endocrine centers. Patients Other Participants: One hundred thirty-five adults AGHD syndrome participated the study. Intervention: Subjects were receive (n = 51), 53), treatment 31) for 32 wk. dose titrated so that IGF-I less than equal +2 sd age-adjusted normal range. Main Outcome Measure: Trunk main outcome measure measured by dual energy x-ray absorptiomet...