ADAMs as Mediators of Angiotensin II Actions

摘要: Other chapters in this book focus on the role that proteolytic processing plays generation and degradation of angiotensin peptides. Such events are crucial to initiation, modulation and/or termination actions at type 1 receptor (AT1) other atypical receptors. In addition, there is increasing awareness following AT1 activation specific, cell surface proteases stimulated cleavage products these make a fundamental contribution downstream actions. Thus, receptors can promote set classical signals attributed their cognate heterotrimeric guanine nucleotide-binding (G) proteins whilst simultaneously activating alternative based shedding extracellular ligands for The most compelling – although still relatively poorly understood example such activity capacity G protein-coupled (GPCRs), as receptor, epidermal growth factor (EGF) which subsequently activate EGF (EGFR) process termed EGFR transactivation. chapter, we major class called ADAMs (a disintegrin metalloprotease) have been strongly implicated ligands, review evidence important enzymes form critical component contribute disease.