Long-term management of plaque and gingivitis using an alcohol-free essential oil containing mouthrinse: a 6-month randomized clinical trial.
作者： Cortelli , Shang H , McGuire Ja , Charles Ca , Cortelli Sc
DOI:
关键词:
摘要: PURPOSE This 6-month, examiner-blind, single center, randomized, parallel group, controlled clinical trial compared the antiplaque/antigingivitis effects of an alcohol-free EO mouthrinse (LISTERINE Zero) to a negative control (5% flavored, colored hydroalcohol) and CPC-containing (Colgate Plax). METHODS 337 gingivitis subjects were clinically examined determine Modified Gingival Index (MGI) Plaque (PI) at baseline, 3 6 months. The primary efficacy variables mean MGI PI months (statistically analyzed by ANCOVA). After professional dental prophylaxis, randomly assigned 6-month twice daily unsupervised use EO, CPC or rinse, in conjunction with normal brushing flossing. Safety was monitored throughout study. RESULTS 311 completed use, significantly reduced plaque (31.6%) (24.0%) control. At months, also (6.4%) (4.4%) provided 26.9% decrease 20.5% (P < 0.001). All rinses well tolerated. demonstrated superior reducing over both mouthrinse.
researchgate.net 参考文章(31)
Weatherford T, Lamm Ra, Ross Nm, Menaker L, Lobene Rr, A modified gingival index for use in clinical trials. Clinical preventive dentistry. ,vol. 8, pp. 3- 6 ,(1986)
Tracie V Blenman, Ana L Medina, Kelly L Morrison, Robert W Gerlach, Grace J Tsau, Practice implications with an alcohol-free, 0.07% cetylpyridinium chloride mouthrinse American Journal of Dentistry. ,(2005)
William DeVizio, Virginia Monsul Barnes, Rose Richter, Evangelia Arvanitidou, Matthew Cronin, Gregory Szewczyk, Schadt Michelle, Evaluation of the antiplaque efficacy of two cetylpyridinium chloride-containing mouthwashes. The Journal of clinical dentistry. ,vol. 22, pp. 200- ,(2011)
Jason Nesta, Lyndsay M Schaeffer, Malcolm I Williams, Evangelia Arvanitidou, Laurence Du-Thumm, Gregory Szewczyk, Mark Vandeven, In vitro antibacterial efficacy of cetylpyridinium chloride-containing mouthwashes. The Journal of clinical dentistry. ,vol. 22, pp. 183- ,(2011)
Sheila Cavalca Cortelli, José Roberto Cortelli, Krista Simmons, Christine Ann Charles, Mei-Miau Wu, Comparative antiplaque and antigingivitis efficacy of a multipurpose essential oil-containing mouthrinse and a cetylpyridinium chloride-containing mouthrinse: A 6-month randomized clinical trial Quintessence International. ,vol. 43, ,(2012)
Soparkar Pm, Newman Mb, Lobene Rr, Use of dental floss. Effect on plaque and gingivitis. Clinical preventive dentistry. ,vol. 4, pp. 5- 8 ,(1982)
C.H. Sissons, L. Wong, T.W. Cutress, Inhibition by ethanol of the growth of biofilm and dispersed microcosm dental plaques. Archives of Oral Biology. ,vol. 41, pp. 27- 34 ,(1996) , 10.1016/0003-9969(95)00103-4
David Herrera, Silvia Roldán, Isabel Santacruz, Sagrario Santos, Mireia Masdevall, Mariano Sanz, Differences in antimicrobial activity of four commercial 0.12% chlorhexidine mouthrinse formulations: an in vitro contact test and salivary bacterial counts study Journal of Clinical Periodontology. ,vol. 30, pp. 307- 314 ,(2003) , 10.1034/J.1600-051X.2003.00341.X
N. SHARMA, C.H. CHARLES, M.C. LYNCH, J. QAQISH, J.A. MCGUIRE, J.G. GALUSTIANS, L.D. KUMAR, Adjunctive benefit of an essential oil–containing mouthrinse in reducing plaque and gingivitis in patients who brush and floss regularly: A six-month study Journal of the American Dental Association. ,vol. 135, pp. 496- 504 ,(2004) , 10.14219/JADA.ARCHIVE.2004.0217
S Haps, DE Slot, CE Berchier, GA Van der Weijden, The effect of cetylpyridinium chloride‐containing mouth rinses as adjuncts to toothbrushing on plaque and parameters of gingival inflammation: a systematic review International Journal of Dental Hygiene. ,vol. 6, pp. 290- 303 ,(2008) , 10.1111/J.1601-5037.2008.00344.X