Lymph node status and survival in cutaneous malignant melanoma--sentinel lymph node biopsy impact.

摘要: Aim: The survival benefit of sentinel lymph node biopsy (SLB) with lymphadenectomy for microscopic melanoma metastases to regional nodes (SLND) is uncertain. aim the study was analyse factors influencing clinical outcome (overall (OS) and disease free (DFS)) patients undergone dissection (LND) as result positive or consequence clinically detected (CLND). Patients methods: This a single-institution retrospective analysis data 350 consecutive, prospectively collected, who underwent radical LND in 1995–2001. One hundred forty-five SLND 205 CLND. Results: median OS DFS times entire group patients, computed from date primary lesion excision, were 46.3 months 26.5 (5-year ratio 41.8% 5-year 31.5%). The which correlated poor by multivariate were: tumour Breslow thickness >4 mm (p=0.001), extracapsular extension (p=0.004), male sex (p=0.001) more than one (p=0.04). negative nodal invasion (p=0.00002) (p=0.004). There no significant differences between CLND groups, when calculated excision. However, if estimated LND, demonstrated significantly better comparison CLND. Conclusion: demonstrates SLB subsequent malignant metastases.