Hydrogels in Tissue Engineering

摘要: The successful engineering of synthetic hydrogels that exhibit key features the natural extracellular matrices has led to significant advances in field tissue engineering. Various chemical and physical approaches have been developed for hydrogel synthesis. While methods rely on presence readily addressable functional groups formation covalent bonds at crosslinking points, utilize weak reversible interactions gelation purposes. In many cases, gels need be covalently stabilized their long term applications Over past decade, evolved from passive scaffolding materials bioactive cell-responsive play a defining role regulation cellular functions growth. Novel with tunable microstructures, mechanical properties, degradation rates engineered. Biological motifs or soluble factors successfully incorporated allow higher level cell-matrix communication. These synthesis resulted production wide variety support growth different types. development next generation biomimetic relies parallel advancements chemistry, cell biology developmental biology.