The effect of dopaminergic stimulation and inhibition on the urinary excretion of aldosterone and kallikrein in spontaneously hypertensive rats

摘要: The effect on the electrolyte balance of a dopaminergic agonist (bromocriptine) and an antagonist (metoclopramide) their renal aldosterone kallikrein excretion were investigated. Ten normotensive Wistar rats ten spontaneously hypertensive (SHR-Wistar Kioto) treated with BCR (4 mg/Kg weight b.i.d.) for 4 days; after week pharmacological wash-out they received MCP (0,5 days. Before treatment at 2nd 4th day each diuresis, urinary aldosterone, kallikrein, sodium, potassium proteins measured. During 24-hour urine collections kept in separate metabolic cages free access to food water. Kallikrein was lower SHR than under basal conditions (p 0.05); potassium, sodium/potassium rate also reduced SHR. After bromocriptine further reduction observed all parameters unchanged both SHR, but showed significant correlation between less 0,001); this condition it seems that control exerted by is greater one dopamine. It may indicate defect natriuretic vasodilator system rats.