Bone strain magnitude is correlated with bone strain rate in tetrapods: implications for models of mechanotransduction

摘要: Hypotheses suggest that structural integrity of vertebrate bones is maintained by controlling bone strain magnitude via adaptive modelling in response to mechanical stimuli. Increased tissue-level and rate have both been identified as potent stimuli leading increased formation. Mechanotransduction models hypothesize osteocytes sense deformation detecting fluid flow-induced drag the bone's lacunar–canalicular porosity. This model suggests osteocyte's intracellular depends on fluid-flow rate, a product gradient, but does not provide mechanism for detection magnitude. Such necessary adapt loads, because an important determinant skeletal fracture. Using gauge data from limb amphibians, reptiles, birds mammals, we strong correlations between across clades employing diverse locomotor styles degrees rhythmicity. The breadth our sample this pattern likely be common feature tetrapod loading. Moreover, finding encoded at tissue level consistent with hypothesis it might cellular level, facilitating adaptation mechanotransduction.