Vestibular Impairment in Dementia

摘要: OBJECTIVE Recent studies suggest an association between vestibular and cognitive function. The goal of the study was to investigate whether function impaired in individuals with mild impairment (MCI) Alzheimer's disease (AD) compared cognitively normal individuals. STUDY DESIGN Cross-sectional study. SETTING Outpatient memory clinic longitudinal observational unit. PATIENTS Older ≥55 years MCI or AD. Age, sex, education-matched controls were drawn from Baltimore Longitudinal Study Aging (BLSA). INTERVENTION Saccular utricular assessed cervical ocular vestibular-evoked myogenic potentials (c- oVEMPs) respectively, horizontal semicircular canal video head impulse testing. MAIN OUTCOME MEASURES Presence absence VEMP responses, amplitude, reflex (VOR) gain measured. RESULTS Forty-seven (MCI N = 15 AD N = 32) underwent testing matched 94 controls. In adjusted analyses, bilaterally absent cVEMPs associated over three-fold odds (OR 3.42, 95% CI 1.33-8.91, p = 0.011). One microvolt increases both cVEMP oVEMP amplitudes decreased 0.28, 0.09-0.93, p = 0.038 OR 0.92, 0.85-0.99, p = 0.036, respectively). There no significant difference VOR groups. CONCLUSIONS These findings confirm extend emerging evidence dysfunction impairment. Further investigation is needed determine causal direction for link peripheral loss