Diabetes Medications: Impact on Inflammation and Wound Healing
作者： Jay J. Salazar , William J. Ennis , Timothy J. Koh
DOI: 10.1016/J.JDIACOMP.2015.12.017
关键词:
摘要: Chronic wounds are a common complication in patients with diabetes that often lead to amputation. These non-healing wounds are described as being stuck in a persistent inflammatory state characterized by accumulation of pro-inflammatory macrophages, cytokines and proteases. Some medications approved for management of type 2 diabetes have demonstrated anti-inflammatory properties independent of their marketed insulinotropic effects and thus have underappreciated potential to promote wound healing …
jdcjournal.com 参考文章(72)
Michelle Tsigoulis, Mahesh Kajil, Milan Gupta, Manoela Fb Braga, Subodh Verma, Hwee Teoh, Adrian Quan, The effects of rosiglitazone on inflammatory biomarkers and adipokines in diabetic, hypertensive patients Experimental & Clinical Cardiology. ,vol. 17, pp. 191- 196 ,(2012)
Schneider A, Langer S, Messmer K, Uhl E, Breidenbach A, Born F, Effect of C-peptide on wound healing and microcirculation in diabetic mice. European Journal of Medical Research. ,vol. 7, pp. 502- 508 ,(2002)
Abolfazl Aslani, Elahe Shabbak, Saeed Safarnezhad, Mehrdad Jafari, Ramin Bidar, Omid Rezvani, A randomized, double-blind, placebo-controlled trial to determine the effects of topical insulin on wound healing. Ostomy Wound Management. ,vol. 55, pp. 22- 28 ,(2009)
Alessandra Bitto, Domenica Altavilla, Gabriele Pizzino, Natasha Irrera, Giovanni Pallio, Michele R Colonna, Francesco Squadrito, Inhibition of inflammasome activation improves the impaired pattern of healing in genetically diabetic mice British Journal of Pharmacology. ,vol. 171, pp. 2300- 2307 ,(2014) , 10.1111/BPH.12557
Narender Nath, Musfiquidin Khan, Manjeet K. Paintlia, Md Nasrul Hoda, Shailendra Giri, Metformin Attenuated the Autoimmune Disease of the Central Nervous System in Animal Models of Multiple Sclerosis Journal of Immunology. ,vol. 182, pp. 8005- 8014 ,(2009) , 10.4049/JIMMUNOL.0803563
Lei Shi, Guang-Shan Tan, Kun Zhang, Relationship of the Serum CRP Level With the Efficacy of Metformin in the Treatment of Type 2 Diabetes Mellitus: A Meta-Analysis. Journal of Clinical Laboratory Analysis. ,vol. 30, pp. 13- 22 ,(2016) , 10.1002/JCLA.21803
S. J. Leibovich, R. Ross, The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. American Journal of Pathology. ,vol. 78, pp. 71- 100 ,(1975)
Rita E Mirza, Milie M Fang, Margaret L Novak, Norifumi Urao, Audrey Sui, William J Ennis, Timothy J Koh, Macrophage PPARγ and impaired wound healing in type 2 diabetes. The Journal of Pathology. ,vol. 236, pp. 433- 444 ,(2015) , 10.1002/PATH.4548
Chengyu Jiang, Adrian T. Ting, Brian Seed, PPAR-γ agonists inhibit production of monocyte inflammatory cytokines Nature. ,vol. 391, pp. 82- 86 ,(1998) , 10.1038/34184
Xuelian Chen, Yan Liu, Xiong Zhang, Topical insulin application improves healing by regulating the wound inflammatory response Wound Repair and Regeneration. ,vol. 20, pp. 425- 434 ,(2012) , 10.1111/J.1524-475X.2012.00792.X