Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein.
作者： Steven Fletcher , Joel A. Drewry , Vijay M. Shahani , Brent D. G. Page , Patrick T. Gunning
DOI: 10.1139/O09-044
关键词:
摘要: Signal transducer and activator of transcription protein 3 (STAT3) is a latent cytosolic factor that widely recognized as being master regulator the cellular functions lead to cancer phenotype. Constitutively activated STAT3 activity routinely observed in human cancers, promoting uncontrolled cell proliferation suppressing apoptosis. Until relatively recently, inhibition transcriptional was achieved indirectly via suppression upstream kinase activators extracellular cytokine (or) growth stimuli. However, forms transcriptionally functional STAT3-STAT3 dimers, providing valid juncture for targeted downstream molecular inhibition. STAT3's prominent role has seen decade innovative novel approaches targeting constitutively active protein-protein complexes. This mini-review outlines progress made towards identifying agents capable silencing aberrant signalling through disruption complexation events.
nrcresearchpress.com参考文章(46)
Richard Jove, Michelle A. Blaskovich, Jiazhi Sun, Saïd M. Sebti, Alan Cantor, James Turkson, Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Research. ,vol. 63, pp. 1270- 1279 ,(2003)
Phyllis A. Svingen, Keith C. Bible, Timothy J. Kottke, Yuan Ping Pang, Scott H. Kaufmann, Kun Xu, Elisabeth Hajdu, Roy H. Bible, Flavopiridol Binds to Duplex DNA Cancer Research. ,vol. 60, pp. 2419- 2428 ,(2000)
James Turkson, Joon S Kim, Shumin Zhang, Jing Yuan, Mei Huang, Matthew Glenn, Eric Haura, Said Sebti, Andrew D Hamilton, Richard Jove, None, Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity Molecular Cancer Therapeutics. ,vol. 3, pp. 261- 269 ,(2004)
Peng Li, Peter Roller, Cyclization strategies in peptide derived drug design. Current Topics in Medicinal Chemistry. ,vol. 2, pp. 325- 341 ,(2002) , 10.2174/1568026023394209
James Turkson, Shumin Zhang, Linda B. Mora, Audrey Burns, Said Sebti, Richard Jove, Platinum compounds that inhibit constitutive stat3 signaling and induce cell cycle arrest and apoptosis of malignant cells Journal of Biological Chemistry. ,vol. 280, pp. 32979- 32988 ,(2012) , 10.1074/JBC.M502694200
Pijus K. Mandal, Patricia A. Heard, Zhiyong Ren, Xiaomin Chen, John S. McMurray, Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics. Bioorganic & Medicinal Chemistry Letters. ,vol. 17, pp. 654- 656 ,(2007) , 10.1016/J.BMCL.2006.10.099
Zengshuan Ma, Ommoleila Molavi, Azita Haddadi, Raymond Lai, Robert A. Gossage, Afsaneh Lavasanifar, Resveratrol analog trans 3,4,5,4'-tetramethoxystilbene (DMU-212) mediates anti-tumor effects via mechanism different from that of resveratrol. Cancer Chemotherapy and Pharmacology. ,vol. 63, pp. 27- 35 ,(2008) , 10.1007/S00280-008-0704-Z
Zhiyong Ren, Larry A Cabell, Timothy S Schaefer, John S McMurray, Identification of a high-affinity phosphopeptide inhibitor of Stat3. Bioorganic & Medicinal Chemistry Letters. ,vol. 13, pp. 633- 636 ,(2003) , 10.1016/S0960-894X(02)01050-8
Khandaker Siddiquee, Shumin Zhang, Wayne C. Guida, Michelle A. Blaskovich, Benjamin Greedy, Harshani R. Lawrence, M. L. Richard Yip, Richard Jove, Mark M. McLaughlin, Nicholas J. Lawrence, Said M. Sebti, James Turkson, Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 7391- 7396 ,(2007) , 10.1073/PNAS.0609757104
Guobin He, Michael Karin, NF-κB and STAT3 - key players in liver inflammation and cancer. Cell Research. ,vol. 21, pp. 159- 168 ,(2011) , 10.1038/CR.2010.183