In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model
作者： F. Intema , H.A.W. Hazewinkel , D. Gouwens , J.W.J. Bijlsma , H. Weinans
DOI: 10.1016/J.JOCA.2010.01.004
关键词:
摘要: Summary Objective The pathogenesis of osteoarthritis (OA) includes cartilage degeneration, synovial inflammation, and bone changes. Slowly, the sequence inter-relationship these features is becoming clearer. Early models OA suggest thinning subchondral plate in addition to trabecular In present study changes were studied canine anterior cruciate ligament transection (ACLT)-meniscectomy model. This model characterized by intra-joint variability with respect damage (predominantly medial) loading (lateral unloading due a shifted axis). Methods 13 Labrador dogs, was induced removal medial meniscus. Twelve weeks later, integrity evaluated histologically using modified Mankin score (0–11), proteoglycan content determined Alcian Blue assay. Bone architecture tibia quantified micro-CT. Results Cartilage severe compartment (Mankin +3.5, glycosaminoglycan (GAG) −28%) mild lateral +1.6, GAG −15%). Thinning porosity only on side (−21%, +87%, respectively). Interestingly, structure did almost not occur (volume fraction −7%) but clear (−20%). Conclusion localized phenomenon related degeneration while are mechanical (un)loading. different mechanisms responsible for should be taken account when designing interpreting studies interfering turnover treatment OA.
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HENRY J. MANKIN, HOWARD DORFMAN, LOUIS LIPPIELLO, ANTRA ZARINS, Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. Journal of Bone and Joint Surgery, American Volume. ,vol. 53, pp. 523- 537 ,(1971) , 10.2106/00004623-197153030-00009
C.T Lindsey, A Narasimhan, J.M Adolfo, Hua Jin, L.S Steinbach, T Link, M Ries, S Majumdar, Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee Osteoarthritis and Cartilage. ,vol. 12, pp. 86- 96 ,(2004) , 10.1016/J.JOCA.2003.10.009
Helga Lorenz, Wolfram Wenz, Mate Ivancic, Eric Steck, Wiltrud Richter, Early and stable upregulation of collagen type II, collagen type I and YKL40 expression levels in cartilage during early experimental osteoarthritis occurs independent of joint location and histological grading Arthritis Research & Therapy. ,vol. 7, pp. 1- 10 ,(2004) , 10.1186/AR1471
C. Sanchez, O. Gabay, C. Salvat, Y.E. Henrotin, F. Berenbaum, Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts Osteoarthritis and Cartilage. ,vol. 17, pp. 473- 481 ,(2009) , 10.1016/J.JOCA.2008.09.007
M J Pond, G Nuki, Experimentally-induced osteoarthritis in the dog. Annals of the Rheumatic Diseases. ,vol. 32, pp. 387- 388 ,(1973) , 10.1136/ARD.32.4.387
S.M. Botter, G.J.V.M. van Osch, J.H. Waarsing, J.C. van der Linden, J.A.N. Verhaar, H.A.P. Pols, J.P.T.M. van Leeuwen, H. Weinans, Cartilage damage pattern in relation to subchondral plate thickness in a collagenase-induced model of osteoarthritis Osteoarthritis and Cartilage. ,vol. 16, pp. 506- 514 ,(2008) , 10.1016/J.JOCA.2007.08.005
Elizabeth A. Messent, Rupert J. Ward, Carol J. Tonkin, Christopher Buckland-Wright, Tibial cancellous bone changes in patients with knee osteoarthritis. A short-term longitudinal study using Fractal Signature Analysis. Osteoarthritis and Cartilage. ,vol. 13, pp. 463- 470 ,(2005) , 10.1016/J.JOCA.2005.01.007
Jennifer Hwang, Won C. Bae, Wendy Shieu, Chad W. Lewis, William D. Bugbee, Robert L. Sah, Increased hydraulic conductance of human articular cartilage and subchondral bone plate with progression of osteoarthritis Arthritis & Rheumatism. ,vol. 58, pp. 3831- 3842 ,(2008) , 10.1002/ART.24069
S.K. Boyd, R. Müller, T. Leonard, W. Herzog, Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis Osteoarthritis and Cartilage. ,vol. 13, pp. 235- 242 ,(2005) , 10.1016/J.JOCA.2004.11.004
S.M. Botter, S.S. Glasson, B. Hopkins, S. Clockaerts, H. Weinans, J.P.T.M. van Leeuwen, G.J.V.M. van Osch, ADAMTS5−/− mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes Osteoarthritis and Cartilage. ,vol. 17, pp. 636- 645 ,(2007) , 10.1016/J.JOCA.2008.09.018