Free radical scavenging activity of the alcoholic extract of Trewia polycarpa roots in arthritic rats.

作者: D Chamundeeswari , J Vasantha , S Gopalakrishnan , E Sukumar

DOI: 10.1016/S0378-8741(03)00143-0

关键词:

摘要: The alcoholic extract of Trewia polycarpa roots (TPE), which exhibited significant anti-inflammatory activity, was evaluated for the possible mode action by studying its antioxidant potential in adjuvant-induced arthritic rats. biological defence system constituting superoxide dismutase, glutathione peroxidase, ascorbic acid showed a increase while lipid peroxide content found to decrease large extent on TPE treatment thereby indicating extracts free radical scavenging property. Histopathological studies too supported anti-arthritic polycarpa.

参考文章(15)
Stanley T. Omaye, J. David Turnbull, Howerde E. Sauberlich, Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods in Enzymology. ,vol. 62, pp. 3- 11 ,(1979) , 10.1016/0076-6879(79)62181-X
John D. Bancroft, Marilyn Gamble, Theory and Practice of Histological Techniques ,(1990)
Robert Arnold Turner, Peter Hebborn, Screening methods in pharmacology Academic Press. ,(1965)
R. Mukherjee, A. Chatterjee, Structure and synthesis of nudiflorine Tetrahedron. ,vol. 22, pp. 1461- 1466 ,(1966) , 10.1016/S0040-4020(01)99443-8
A E Holley, K H Cheeseman, Measuring free radical reactions in vivo British Medical Bulletin. ,vol. 49, pp. 494- 505 ,(1993) , 10.1093/OXFORDJOURNALS.BMB.A072626
Hiroshi Ohkawa, Nobuko Ohishi, Kunio Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Analytical Biochemistry. ,vol. 95, pp. 351- 358 ,(1979) , 10.1016/0003-2697(79)90738-3
Ronald D. Plattner, Barry E. Jones, Richard G. Powell, Cecil R. Smith, Additional New Maytansinoids from Trewia nudiflora: 10-Epitrewiasine and Nortrewiasine Journal of Natural Products. ,vol. 46, pp. 660- 666 ,(1983) , 10.1021/NP50029A012
A. S. WILLIAMS, J. P. CAMILLERI, B. D. WILLIAMS, SUPPRESSION OF ADJUVANT-INDUCED ARTHRITIS BY LIPOSOMALLY CONJUGATED METHOTREXATE IN THE RAT Rheumatology. ,vol. 33, pp. 530- 533 ,(1994) , 10.1093/RHEUMATOLOGY/33.6.530
Eugene E. Quist, Regulation of erythrocyte membrane shape by Ca2 Biochemical and Biophysical Research Communications. ,vol. 92, pp. 631- 637 ,(1980) , 10.1016/0006-291X(80)90380-0
A Meister, Selective modification of glutathione metabolism Science. ,vol. 220, pp. 472- 477 ,(1983) , 10.1126/SCIENCE.6836290