Structure and function in the uracil-DNA glycosylase superfamily

作者: Laurence H Pearl

DOI: 10.1016/S0921-8777(00)00025-2

关键词:

摘要: … for uracil in DNA, and show negligible activity towards the natural DNA bases cytosine or thymine, or uracil in RNA. … on ss-uracil-DNA, and lacking the conserved catalytic residues and …

参考文章(37)
M L Dodson, M L Michaels, R S Lloyd, Unified catalytic mechanism for DNA glycosylases. Journal of Biological Chemistry. ,vol. 269, pp. 32709- 32712 ,(1994) , 10.1016/S0021-9258(20)30047-8
P Neddermann, J Jiricny, The purification of a mismatch-specific thymine-DNA glycosylase from HeLa cells. Journal of Biological Chemistry. ,vol. 268, pp. 21218- 21224 ,(1993) , 10.1016/S0021-9258(19)36913-3
Brian Hendrich, Ulrike Hardeland, Huck-Hui Ng, Josef Jiricny, Adrian Bird, The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites Nature. ,vol. 401, pp. 301- 304 ,(1999) , 10.1038/45843
Tracey E Barrett, Renos Savva, George Panayotou, Tom Barlow, Tom Brown, Josef Jiricny, Laurence H Pearl, Crystal Structure of a G:T/U Mismatch-Specific DNA Glycosylase Cell. ,vol. 92, pp. 117- 129 ,(1998) , 10.1016/S0092-8674(00)80904-6
Alexander C. Drohat, Gaoyi Xiao, Maria Tordova, Jaya Jagadeesh, Krzysztof W. Pankiewicz, Kyoichi A. Watanabe, Gary L. Gilliland, James T. Stivers, Heteronuclear NMR and crystallographic studies of wild-type and H187Q Escherichia coli uracil DNA glycosylase: electrophilic catalysis of uracil expulsion by a neutral histidine 187. Biochemistry. ,vol. 38, pp. 11876- 11886 ,(1999) , 10.1021/BI9910880
Clifford D Mol, Andrew S Arvai, Geir Slupphaug, Bodil Kavli, Ingrun Alseth, Hans E Krokan, John A Tainer, Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis. Cell. ,vol. 80, pp. 869- 878 ,(1995) , 10.1016/0092-8674(95)90290-2
Geir Slupphaug, Clifford D. Mol, Bodil Kavli, Andrew S. Arvai, Hans E. Krokan, John A. Tainer, A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA. Nature. ,vol. 384, pp. 87- 92 ,(1996) , 10.1038/384087A0