Traffic-Related Particulate Matter and Cardiometabolic Syndrome: A Review

摘要: Traffic-related particulate matter (PM) is a major source of outdoor air pollution worldwide. It has been recently hypothesized to cause cardiometabolic syndrome, including cardiovascular dysfunction, obesity, and diabetes. The environmental toxicological factors involved in the processes, detailed mechanisms remain be explored. objective this study assess current scientific evidence traffic-related PM-induced syndrome. We conducted literature review by searching keywords “traffic related pollution”, “particulate matter”, “human health”, “metabolic syndrome” from 1980 2018. This resulted 25 independent research studies for final review. Both epidemiological findings reveal consistent correlations between PM exposure measured health endpoints. Smaller sizes PM, particularly ultrafine particles, are shown more harmful due their greater concentrations, reactive compositions, longer lung retention, bioavailability. active components could attributed metals, black carbon, elemental polyaromatic hydrocarbons, diesel exhaust particles. Existing points out that development symptoms can occur through chronic systemic inflammation increased oxidative stress. elderly (especially women), children, genetically susceptible individuals, people with pre-existing conditions identified as vulnerable groups. To advance characterization potential risks additional needed investigate chemical compositions constituents, atmospheric transformations, mode action induce adverse effects. Furthermore, we recommend future explore roles genetic epigenetic influencing outcomes integrating multi-omics approaches (e.g., genomics, epigenomics, transcriptomics) provide comprehensive assessment biological perturbations caused PM.