Adherence of type I Streptococcus pneumoniae to tracheal epithelium of mice infected with influenza A/PR8 virus.

摘要: Bacterial adherence to virus-infected respiratory tract cells may be one of the several mechanisms whereby virus predisposes bacterial pneumonia. To evaluate effect influenza infection on pneumococcus adhesion, 39 mice were infected with PR8/A virus. The radiolabeled tracheal was determined 2, 4, and 6 days after viral inoculation. pneumococcal adhesion tracheas significantly enhanced Day (p less than 0.001). Scanning transmission electron microscopy revealed that by fourth sixth inoculation, ciliated secretory epithelium had desquamated mucosa coated a continuous layer basal cells. In few cases, desquamation observed exposed basement membrane appeared as pole attraction for bacteria. Pneumococci never seen attached control tracheas. contrast, they adhered microvilli and, greater extent, membrane.