Serum protein changes in monkeys infected with Schistosoma mansoni, with special reference to the metabolism of albumin

摘要: 1. 1. Studies have been carried out on the serum protein changes in seven rhesus monkeys infected with Schistosoma mansoni, using biuret method of determination and paper electrophoresis. On three these monkeys, blood volume distribution metabolism albumin were investigated simultaneously, homologous 131I-Iabelled albumin. 2. 2. A sudden change concentration proteins occurs 6 to 7 weeks after initial infection, i.e., about time when eggs first appear faeces. The consists an increase gamma-globulin concentration; usually total and, at least heavy infections, a decrease some there is rise beta globulin concentration. When resistant are “challenged” large numbers cercariae, similar occur earlier, 2 exposure. 3. 3. isotope studies show that associated fall body intravascular subsequent rapid recovery, marked “catabolic” rate, followed by slow return normal. Between 8th 12th week infection ratio, signifying size extravascular pool albumin; this normal. 4. 4. It believed due catabolism incompletely compensated anabolism.