[4] Suppression of hydroxyl radical reactions in biological systems: Considerations based on competition kinetics

摘要: Publisher Summary This chapter provides information to the suppression of hydroxyl radical (•OH) reactions in biological systems. Hydroxyl-radical-induced form an essential part many degradative processes that afflict life. In aqueous and oxygenated media, •OH radicals arise various ways. These include Fenton-type involving biogenic H 2 O , which is a product dismutation superoxide; latter mainly side incidental respiration enzymatic oxidation processes, decomposition certain peroxyl radicals, or inflammatory tissues. Hydroxyl are also produced by ionizing radiation. Chemical damage cell constituents carry out critical functions, such as DNA, may have serious consequences. It therefore natural reflect on way deleterious might be mitigated intervention drugs. Thus involvement free systems has become important issue medicine, concepts based knowledge underlying developed for treatment diseases with some measure success.