Pathological and protective roles of glia in chronic pain
作者： Erin D. Milligan , Linda R. Watkins
DOI: 10.1038/NRN2533
关键词:
摘要: Glia have emerged as key contributors to pathological and chronic pain mechanisms. On activation, both astrocytes microglia respond release a number of signalling molecules, which protective and/or functions. Here we review the current understanding contribution glia neuroprotection, how protective, anti-inflammatory actions are being harnessed develop new drug targets for neuropathic control. Given prevalence partial efficacy drugs, exclusively target neuronal mechanisms, strategies manipulate neuron–glia interactions in processing hold considerable promise.
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