Expression and Function of Tetraspanins and Their Interacting Partners in B Cells.

摘要: Tetraspanins are transmembrane proteins that modulate multiple diverse biological processes including signal transduction, cell-cell communication, immunoregulation, tumorigenesis, cell adhesion, migration, and growth differentiation. Here we provide a systematic review of the involvement tetraspanins their partners in regulation function B cells mechanisms associated with antigen presentation, antibody production, cytokine secretion, co-stimulator expression, immunosuppression. Finally, direct our focus to signaling mechanisms, evolutionary conservation aspects, potential therapeutic strategies could be based on interacting partners.