Handling heme: The mechanisms underlying the movement of heme within and between cells.

摘要: Heme is an essential cofactor and signaling molecule required for virtually all aerobic life. However, excess heme cytotoxic. Therefore, must be safely transported trafficked from the site of synthesis in mitochondria or uptake at cell surface, to hemoproteins most subcellular compartments. While degradation are relatively well characterized, little known about how throughout cell. Herein, we review eukaryotic transport, trafficking, mobilization, with a focus on factors that regulate bioavailable heme. We also highlight role gasotransmitters small molecules mobilization bioavailability, trafficking host-pathogen interface.