Intraspinal nerve terminals immunoreactive for tyrosine hydroxylase, serotonin and substance P in guinea-pigs with acute experimental allergic encephalomyelitis.

摘要: Abstract Spinal cord axons and terminals stained for tyrosine hydroxylase-, serotonin- substance P-like immunoreactivity were examined in guinea-pigs the paraplegic phase of acute experimental allergic encephalomyelitis, an animal disease model multiple sclerosis. Fibers positive monoamine staining that terminated lumbar ventral horn appeared to be markedly damaged during disease. However, no changes detected those P-containing fibers dorsal horn. It was concluded small diameter, thinly myelinated or unmyelinated course long distances spinal cord, and, therefore, have a high probability encountering inflammatory foci, are particularly vulnerable damage encephalomyelitis. Damage these monoaminergic peptidergic may contribute neurological deficits associated with this autoimmune nervous system