Infantile scurvy: a historical perspective.

摘要: Scurvy, a disease of dietary deficiency vitamin C, is uncommon today. Among diseases, scurvy has rich history and an ancient past. The Renaissance (14th to 16th centuries) witnessed several epidemics among sea voyagers. In 1747, James Lind, British Naval surgeon, performed carefully designed clinical trial concluded that oranges lemons had the most antiscorbutic effect. Eventually, with provision lemon juice voyagers, became rare at sea. Infantile appeared almost as new toward end 19th century. increased incidence infantile during period was attributed usage heated milk proprietary foods. Thomas Barlow described classic pathologic features in 1883. Between 1907 1912, Holst Frolich induced cured guinea pigs by modification. 1914, Alfred Hess established pasteurization reduced value recommended supplementation fresh fruit vegetable juices prevent scurvy. Such pioneering efforts led eradication United States. A brief provided.