Adjuvant Fluorouracil, Leucovorin, and Oxaliplatin in Stage II to III Colon Cancer: Updated 10-Year Survival and Outcomes According to BRAF Mutation and Mismatch Repair Status of the MOSAIC Study
作者： Thierry André , Armand De Gramont , Dewi Vernerey , Benoist Chibaudel , Franck Bonnetain
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摘要: Purpose The MOSAIC (Multicenter International Study of Oxaliplatin/Fluorouracil/Leucovorin in the Adjuvant Treatment Colon Cancer) study has demonstrated 3-year disease-free survival (DFS) and 6-year overall (OS) benefit adjuvant oxaliplatin stage II to III resected colon cancer. This update presents 10-year OS DFS by mismatch repair (MMR) status BRAF mutation. Methods Survival actualization after follow-up was performed 2,246 patients with We assessed MMR mutation 1,008 formalin-fixed paraffin-embedded specimens. Results After a median 9.5 years, rates bolus/infusional fluorouracil plus leucovorin (LV5FU2) LV5FU2 (FOLFOX4) arms were 67.1% versus 71.7% (hazard ratio [HR], 0.85; P = .043) whole population, 79.5% 78.4% for (HR, 1.00; .980), 59.0% 0.80; .016) disease. Ninety-five (9...
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