The influence of gene expression profiling on decisional conflict in decision making for early-stage breast cancer chemotherapy

摘要: Abstract Background Women with early-stage breast cancer, of whom only 15% will experience a recurrence, are often conflicted or uncertain about taking chemotherapy. Gene expression profiling (GEP) tumours informs risk prediction, potentially affecting treatment decisions. We examined whether receiving GEP test score reduces decisional conflict in chemotherapy decision making. Methods A general population sample 200 women completed the scale (DCS) at baseline (no scenario) and after (scenario added) completing discrete choice experiment survey for cancer scaled 16-item DCS total scores subscores from 0 to 100 calculated means, standard deviations change scores, significance (p  Results identified five respondent subgroups based on preferred option; almost 40% did not their testing information. Total all (uncertainty, informed, values clarity, support, effective decision) decreased significantly subgroup who were unsure initially but changed no (n =33). In respondents (n = 25) chose unsure, subscore increased significantly. overall sample, changes non-significant. Conclusions adds value decrease conflict. However, confident decisions, may add value. Decisions request should be personalised patient preferences.