Epidemiologic studies of environmental exposures in Parkinson's disease

摘要: Parkinson's disease (PD) is the most common cause of parkinsonian syndromes and frequent neurodegenerative after Alzheimer's disease. Because ageing Western populations, an increasing number persons will be affected with PD in future neither curative treatments nor preventive measures have been identified. considered as a multifactorial disease, resulting from effect environmental factors genetic susceptibility. Increasing age male sex appear to associated increased risk PD. In addition, recent epidemiological studies identified exposures that influence This review provides overview epidemiologic evidence for etiologies PD; we focus on two quite consistently - cigarette smoking pesticide exposure summarize briefly findings other exposures. Understanding mechanisms underlying these associations essential step understanding etiology this condition and, ideally, develop neuroprotective drugs.