Gastroesophageal Reflux and Barrett’s Esophagus

摘要: In 1950, Norman Rupert Barrett, an Australian-born thoracic surgeon (Fig. 1; 1903–1979), described ulcers in the lower esophagus, previously attributed to gastroesophageal reflux (GER) by Allison [3], as fact “chronic peptic ulcers“ within intrathoracic stomach assuming a tubular form secondary “short esophagus“ [10]. Three years later it was [4] that corrected Barrett’s misinterpretation and condition we now understand it, namely columnar metaplasia replacing normally squamous epithelium of termed this “Barrett’s Esophagus.“ Over last 50 definition esophagus (BE) has continued evolve, spite his original erroneous description, day remains eponymous Barrett. We describe advances have been made over these contributed our understanding pathophysiology management very difficult adults then focus on aspects disease specific pediatric population.