Acrosome reaction is impaired in spermatozoa of obese men: a preliminary study

摘要: Objective To compare spontaneous (Sp-AR) and P-induced acrosome reaction (AR) in spermatozoa of obese lean subjects. Setting Bariatric unit at a university hospital. Design Prospective, observational study. Patient(s) Twenty-three (mean ± SD body mass index [BMI], 44.3 5.9 kg/m 2 ) 25 age-matched (BMI, 24.2 3.0 kg/m Intervention(s) None. Main Outcome Measure(s) Spontaneous AR Result(s) A statistically significant difference was found between cohorts total T calculated free T, E , glycated hemoglobin, high-density lipoproteins, whereas among the routine semen parameters analyzed, only immotile sperm percentage ejaculate volume differed significantly. Spermatozoa (n = 13) vs. men 19) showed higher Sp-AR (17.9% 7.2% 8.3% 4.2%), which resulted reduced ability to respond P evaluated as AR-after-P-challenge parameter (3.5% 3.2% 17.6% 9.2%). Multivariate analysis adjusted for age revealed correlation BMI, waist, hemoglobin with both (age-adjusted r 0.654, 0.711, 0.369, 0.644, respectively) r=−0.570, −0.635, −0.507, −0.563, respectively). cholesterol content reported (29.8 19.5 19.1 14.6 ng/μg proteins). Conclusion(s) Sperm is impaired men, showing response elevated Sp-AR, associated altered circulating levels content.