Bisphenol A affects endocrine physiology and biotransformation enzyme activities of the field vole (Microtus agrestis).

摘要: Bisphenol A (BPA), an environmental estrogen, was given subcutaneously for 4 days to 48 field voles at three doses (10, 50, or 250 mg kg−1 day−1). Plasma sex steroids, thyroxine, weight-regulatory hormones, and liver biotransformation enzymes were determined. There no mortality in the control group but BPA-exposed animals significant. BPA increased plasma testosterone concentrations day−1. The ghrelin levels measured from pooled same time leptin decreased 50 7-ethoxyrufin-o-deethylase activity slightly all doses, as did cytosolic glutathione S-transferase results show that wild mammals such vole could be more susceptible than laboratory rodents. More studies on are needed determine risks of endocrine disruptors natural ecosystems.