Interplay between cortical actin and E-cadherin dynamics regulates cell shape in the Drosophila embryonic epidermis
作者： Joshua Greig , Natalia A. Bulgakova
DOI: 10.1101/801456
关键词:
摘要: Abstract Precise regulation of cell shape is vital for building functional tissues. Here, we study the mechanisms which lead to formation highly elongated anisotropic epithelial cells in Drosophila epidermis. We demonstrate that this result two counteracting at surface: actomyosin, inhibits elongation downstream RhoA signalling, and intercellular adhesion, modulated via clathrin-mediated endocytosis E-cadherin, promotes GTPase Arf1. show these are interconnected, with signalling activity reducing Arf1 recruitment plasma membrane. Additionally, adhesion itself regulates both mechanisms: p120-catenin, a regulator RhoA. Altogether, uncover complex network interactions between cell-cell endocytic machinery, actomyosin cortex, how an tissue vivo.
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