Mucosal immune response of Nile tilapia Oreochromis niloticus during Gyrodactylus cichlidarum infection

摘要: Monogenean Gyrodactylus cichlidarum can cause severe mortality of Nile tilapia (Oreochromis niloticus) fry. To date, reports about mucosal immunity O. niloticus against this parasite have been rare. In order to explore the G. infection, expressions six adaptive immune-related genes and contents specific immunoglobulin IgM IgT in skin-associated lymphoid tissues (SALT) were dynamically analyzed after primary secondary infections. The abundances on hosts infection lower than those which implied that could initiate immune protection reinfection some degree. transcription levels TCR-β CD4 skin tissue significantly up-regulated while pIgR only detected with significant up-regulations during infection. With exception pIgR, had remarkably higher expression fish low loads, all other studied tended mRNA level loads. content mucus increased 2nd day exposure, corresponding value positive correlation loads first These results manifested acquired responses SALT participated resistance underscoring involvement monogenean suggesting potential prophylactic treatment gyrodactylid disease tilapia.