Effect of timing and method of enteral tube feeding for dysphagic stroke patients (FOOD): a multicentre randomised controlled trial.

摘要: Background: Undernutrition is common in patients admitted with stroke. We aimed to establish whether the timing and route of enteral tube feeding after stroke affected patients' outcomes at 6 months. Methods: The FOOD trials consist three pragmatic multicentre randomised controlled trials, two which included dysphagic patients. In one trial, enrolled within 7 days admission were randomly allocated early or no for more than (early versus avoid). other, percutaneous endoscopic gastrostomy (PEG) nasogastric feeding. primary outcome was death poor Analysis by intention treat. Findings: Between Nov 1, 1996, July 31, 2003, 859 83 hospitals 15 countries into avoid trial. Early associated an absolute reduction risk 5.8% (95% CI -0.8 12.5, p=0.09) a 1.2% (-4.2 6.6, p=0.7). PEG 321 47 11 countries. increase 1.0% (-10.0 11.9, p=0.9) increased 7.8% (0.0 15.5, p=0.05). Interpretation: might reduce case fatality, but expense increasing proportion surviving outcome. Our data do not support policy initiation