The Role of Lactate-Mediated Metabolic Coupling between Astrocytes and Neurons in Long-Term Memory Formation.

摘要: Long-term memory formation, the ability to retain information over time about an experience, is a complex function that affects multiple behaviors, and integral part of individual’s identity. In last 50 years many scientists have focused their work on understanding biological mechanisms underlying formation processing. Molecular studies three decades mostly investigated, or given attention to, neuronal mechanisms. However, brain composed different cell types that, by concerted actions, cooperate mediate functions. Here we consider some new insights emerged from recent implicating astrocytic glycogen glucose metabolisms, particularly coupling functions via lactate, as essential mechanism for long-term formation.