Synaptic Membranes Bend to the Will of a Neurotoxin

作者: Joshua Zimmerberg , Leonid V Chernomordik

DOI: 10.1126/SCIENCE.1122439

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摘要: In their Perspective, Zimmerberg and Chernomordik discuss the study by Rigoni et al. same issue that shows how lipid products of a phospholipase present in snake venom reproduce known paralytic effect lipase itself on presynaptic action neuromuscular junction. The shift curvature synaptic membranes toward or away from intermediate states membrane fusion. This suggests hemifusion state vesicle release explains existence rapid spontaneous neurotransmitter vesicles.

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