X-Ray Crystallography of Biological Macromolecules
作者： Albrecht Messerschmidt , Robert Huber
DOI: 10.1002/9780470027318.A1634
关键词:
摘要: X-ray crystallography of biological macromolecules comprises the determination three-dimensional structures proteins, nucleic acids and other at atomic resolution by diffraction X-rays on crystals such macromolecules. The structure is obtained from electron density distribution macromolecular crystal, which Fourier transform waves diffracted crystal. amplitudes are determined directly experiment. phases revealed (i) additional data isomorphous heavy atom derivatives [multiple replacement (MIR) technique], (ii) multiple anomalous (MAD), if suitable scatterers in crystal using tunable synchrotron radiation, (iii) Patterson search techniques (molecular replacement), structural information macromolecule under investigation available. unique method for elucidation spatial complex biomolecules with molecular masses greater than 30 kDa. represent a time average molecules packed preparation may be limiting factor.
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