Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury.

摘要: The pathogenesis of septic myocardial depression is complicated. Mitochondrial dysfunction has been suggested to be one the main reasons for reduced cardiac function. As melatonin an antioxidant with potential scavenge radicals in mitochondria, we therefore employed a sepsis model, that is, cecal ligation and double puncture (CLP) rats, study effects on: (i), mitochondrial function; (ii), heart systolic (iii), prognosis rats. We demonstrate treatment (30 mg/kg, 3, 6, 12, 18, 24 hr after CLP) (i) improved cytochrome c oxidase (CcOX) activity blood lactate level, (ii) attenuated higher left ventricular ejection fraction (EF), (iii) promoted 48-h survival rats compared CLP animals no treatment. In conclusion, our results show rat CcOX was depressed during severe accompanied by characterized decline EF. increased activity, function, lowered mortality rate. clinical use should tested future.