The phenotypic variability of amyotrophic lateral sclerosis

摘要: Amyotrophic lateral sclerosis (ALS) is a genotypically and phenotypically heterogeneous disease, as reflected in the variability age site of onset, extent extramotor involvement, survival. Cognitive involvement also common, corroborates connection between ALS frontotemporal lobar degeneration. In this article, Robberecht Swinnen review phenotypic heterogeneity discuss some its implications for understanding pathogenesis development therapeutic interventions.