Pulmonary arterial hypertension in rats due to age-related arginase activation in intermittent hypoxia.
作者： Akina Nara , Hisashi Nagai , Kaori Shintani-Ishida , Sayoko Ogura , Tatsuo Shimosawa
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摘要: Pulmonary arterial hypertension (PAH) is prevalent in patients with obstructive sleep apnea syndrome (OSAS). Aging induces arginase activation and reduces nitric oxide (NO) production the arteries. Intermittent hypoxia (IH), conferred by cycles of brief normoxia, contributes to OSAS pathogenesis. Here, we studied role aging pathogenesis PAH adult (9-mo-old) young (2-mo-old) male Sprague-Dawley rats subjected IH or normoxia for 4 weeks analyzed them a pressure-volume catheter inserted into right ventricle (RV) pulsed Doppler echocardiography. Western blot analysis was conducted on arginase, NO synthase isoforms, nitrotyrosine. induced PAH, as shown increased RV systolic pressure hypertrophy, but not rats. expression levels I II proteins also pulmonary artery endothelium ar...
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