Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?
作者： Simone Cristina Soares Brandão , Júlia de Oliveira Xavier Ramos , Luca Terracini Dompieri , Emmanuelle Tenório Albuquerque Madruga Godoi , José Luiz Figueiredo
DOI: 10.1016/J.CYTOGFR.2020.09.002
关键词:
摘要: The severe form of COVID-19 is marked by an abnormal and exacerbated immunological host response favoring to a poor outcome in significant number patients, especially those with obesity, diabetes, hypertension, atherosclerosis. chronic inflammatory process found these cardiometabolic comorbidities the overexpression pro-inflammatory cytokines such as interleukin-6 (IL-6) tumoral necrosis factor-alpha (TNF-α), which are products Toll-Like receptors 4 (TLR4) pathway. SARS-CoV-2 initially infects cells upper respiratory tract and, some spread very quickly, needing support systemically, causing collateral damage tissues. We hypothesize that this happens because spike protein interacts strongly TLR4, intensely immune host's lungs, culminating cytokine storm, accumulating secretions hindering blood oxygenation, along system attacks body, leading multiple organ failure.
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