Post-vaccination serological test results of infants at risk of perinatal transmission of hepatitis B using an intensified follow-up programme in a London centre
作者： Cheuk Y.W. Tong , Carol Robson , Yin Wu , Rozanna Issa , Timothy Watts
DOI: 10.1016/J.VACCINE.2013.04.083
关键词:
摘要: Abstract Immunisation of infants born to hepatitis B virus (HBV) infected mothers is an important public health measure prevent mother-to-child transmission HBV. Post-vaccination serological tests (PVST) inform the success infant HBV immunisation programme and identify infants. Previous studies suggested that rates PVST in UK were unsatisfactory. We introduced intensified local follow-up offered earlier 2–3 months after third vaccination at age 4–5 months. Of 219 between 2009 2011, 193 (88.1%) had least one PVST: 145 (66.2%) early; 94 (42.9%) standard; 46 (21.0%) both 26 (11.9%) never tested. Twenty-four identified as high risk for according national criteria received immunoglobulin (HBIG) vaccine birth. These a significantly lower surface antibody (anti-HBs) levels early compared group who only (median 59 vs. 376 mIU/ml, P = 0.006). None tested with B. This study illustrates rate can be improved by using offering PVST. The anti-HBs HBIG subgroup concern this already higher acquiring infection. Infants poor responses timely extra booster dose.
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