Regulation of Growth and Secretion of Growth Factors by 17 B-Estradiol and V-RASH Oncogene in Human Mammary Carcinoma Cell Lines

摘要: Breast cancer is unique among cancers in that its growth strongly regulated about one third of clinical cases by estrogenic hormones or antiestrogenic antagonists (1). occurs women who never had functional ovaries with only 1% the frequency intact ovaries. Thus, estrogens are stimulatory, at least initially, nearly all breast cancers. This hormonal component control appears to be a remnant normal, differentiated epithelial proliferation. During puberty pregnancy-lactation, estrogen exerts mitogenic, anabolic and secretory effects on mammary epithelium. While proximate mitogen for either normal malignant epithelium, hypothalamus-pituitary axis indirectly ovarian secretion virtue gonadotropin releasing hormone stimulation (2).