Recent developments in glycosyl urea synthesis

摘要: The area of sugar urea derivatives has received considerable attention in recent years because the unique structural properties and activities that these compounds display. urea-linkage at anomeric center is a robust alternative to naturally occurring O- N-glycosidic linkages oligosaccharides glycoconjugates, natural products have been identified contain structures show remarkable biological activity. While methods for installing β-urea-linkage around decades, first synthesis α-urea glycosides much more recent. In either case, selective glycosyl ureas can be quite challenging, mixture α- β-isomers will often result. This paper provide comprehensive review synthetic approaches β-urea examine structure activity their analogues them.