Optogenetic inhibition of chemically induced hypersynchronized bursting in mice.

摘要: Synchronized activity is common during various physiological operations but can culminate in seizures and consequently epilepsy pathological hyperexcitable conditions the brain. Many types of are not possible to control impose significant disability for patients with epilepsy. Such intractable cases often associated degeneration inhibitory interneurons cortical areas resulting impaired drive onto principal neurons. Recently emerging optogenetic technique has been proposed as an alternative approach such whether it may be effective situations where processes brain compromised addressed. Here we used pharmacological techniques block neurotransmission induce epileptiform vitro vivo. We demonstrate that NpHR-based hyperpolarization thereby inactivation a neuronal population hippocampus effectively attenuating seizure caused by disconnected network inhibition both Our data suggest controlled silencing neurons potentially developed treatment