INHERITED METABOLIC DISORDERS: ERRORS OF PHENYLALANINE AND TYROSINE METABOLISM.

摘要: Publisher Summary The study of inborn defects in the metabolism phenylalanine and tyrosine has been one most rewarding chapters biochemistry genetics. discovery that individuals with alkaptonuria excreted homogentisic acid, as well demonstration structural relation this to tyrosine, leads elucidation main pathway tyrosine. chapter discusses an effective dietary treatment for phenylketonuria was stimulus that, by proving mental abnormalities were because intoxication finally disproving pleiotropic gene theory, raised hope schizophrenia would also be found caused arising from a metabolic error might curable some comparable means. explores normal is considered through secondary pathways leading melanin, norepinephrine, epinephrine, their breakdown products, normally minor phenylpyruvic p-hydroxyphenyllactic amines.