Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer.

摘要: Phosphodiesterase-5 (PDE5) inhibitors are suggested to have anti-tumor effects and to inhibit surgery-induced immunosuppression. We aimed explore whether post-diagnostic use of PDE5 was associated with a better prognosis among male patients colorectal cancer (CRC) the role open surgery in association. Here we show that is decreased risk CRC-specific mortality (adjusted HR = 0.82, 95% CI 0.67-0.99) as well metastasis HR = 0.85, 0.74-0.98). Specifically, post-operative has a strong anti-cancer effect. The reduced mainly due distant but not regional lymphatic metastasis. potential be an adjuvant drug for CRC improve prognosis, especially those who undergone surgery. been effect block Here, authors postdiagnostic cancerspecific