Impaired executive functions in experimental model of temporal lobe epilepsy.
作者： Fabiane Ochai Ramos , Luiz Renato Rodrigues Carreiro , Fulvio Alexandre Scorza , Roberta Monterazzo Cysneiros
DOI: 10.1590/0004-282X20160070
关键词:
摘要: Objective The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats temporal lobe epilepsy (TLE). Method Male at 25 day of age were submitted animal model TLE by pilocarpine injection (350 mg/kg, ip) a control group received saline 0.9%. animals continuously video monitored up the end experiments. tests (open field, elevated plus maze operant conditioning box) started from 60 days postnatal. Results Animals exhibited locomotor activity, reduced level anxiety-related behavior, impulsivity impaired visuospatial working memory. Conclusion Taken as whole, we concluded that some ADHD-like behavior.
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