Anthracycline derivatives as solubilized pro-drugs

摘要: The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions may be converted such pro-drugs. are hydrolyzed in the body, regenerating original drugs release a salt phosphoric acid.