Fabrication and Response Characteristics of the Light Addressable Potentiometric Sensor for Detecting the Penicillin Concentration
作者： Su-Won Jang , Young-Hee Jung , Jin-Ho Park , Jea-Ho Kim , Dae-Hyuk Kwon
DOI: 10.5369/JSST.2004.13.5.356
关键词:
摘要: In this study, we developed the measuring system based on light addressable potentiometric sensor for quantitative analysis of penicillin that is very important element in medicine and pharmacy, clinic. It investigated response characteristics by enzyme reaction with penicillinase. First, surface pre-treatment process was established. The coupling agent made using self assembled monolayer method it confirmed immobilization AFM. Also, as system, potentiostat, signal processing part etc. Lab VIEW software, reduced detecting time well simplifying system. Fabricated device shown excellent pH characteristics, 57 mV/ range . 60 mV/decade
koreascience.or.kr参考文章(15)
Atsushi Seki, Syuu-ichi Ikeda, Izumi Kubo, Isao Karube, BIOSENSORS BASED ON LIGHT-ADDRESSABLE POTENTIOMETRIC SENSORS FOR UREA, PENICILLIN AND GLUCOSE Analytica Chimica Acta. ,vol. 373, pp. 9- 13 ,(1998) , 10.1016/S0003-2670(98)00364-X
Brian G Healey, Lin Li, David R Walt, Multianalyte biosensors on optical imaging bundles Biosensors and Bioelectronics. ,vol. 12, pp. 521- 529 ,(1997) , 10.1016/S0956-5663(97)00009-2
Steve. Caras, Jiri. Janata, Field effect transistor sensitive to penicillin Analytical Chemistry. ,vol. 52, pp. 1935- 1937 ,(1980) , 10.1021/AC50062A035
A. Poghossian, M.J. Schöning, P. Schroth, A. Simonis, H. Lüth, An ISFET-based penicillin sensor with high sensitivity, low detection limit and long lifetime Sensors and Actuators B: Chemical. ,vol. 76, pp. 519- 526 ,(2001) , 10.1016/S0925-4005(01)00609-8
A.P. Soldatkin, J. Montoriol, W. Sant, C. Martelet, N. Jaffrezic-Renault, A novel urea sensitive biosensor with extended dynamic range based on recombinant urease and ISFETs. Biosensors and Bioelectronics. ,vol. 19, pp. 131- 135 ,(2003) , 10.1016/S0956-5663(03)00175-1
Christian Eppelsheim, Ralph Aubeck, Norbert Hampp, Comparison of potentiometric enzyme sensors for urea and penicillin-G: differential thick-film sensors versus classical electrodes Journal of Membrane Science. ,vol. 100, pp. 131- 137 ,(1995) , 10.1016/0376-7388(94)00256-X
T Yoshinobu, H Ecken, A.B Md. Ismail, H Iwasaki, H Lüth, M.J Schöning, Chemical imaging sensor and its application to biological systems Electrochimica Acta. ,vol. 47, pp. 259- 263 ,(2001) , 10.1016/S0013-4686(01)00564-3
Shinji Inoue, Motoi Nakao, Tatsuo Yoshinobu, Hiroshi Iwasaki, Chemical-imaging sensor using enzyme Sensors and Actuators B-chemical. ,vol. 32, pp. 23- 26 ,(1996) , 10.1016/0925-4005(96)80104-3
D. Hafeman, J. Parce, H. McConnell, Light-addressable potentiometric sensor for biochemical systems. Science. ,vol. 240, pp. 1182- 1185 ,(1988) , 10.1126/SCIENCE.3375810
W. Höbel, A. Papperger, J. Polster, Penicillinase optodes : substrate determinations using batch, continuous flow and flow injection analysis operation conditions Biosensors and Bioelectronics. ,vol. 7, pp. 549- 557 ,(1992) , 10.1016/0956-5663(92)85006-V