Anabolic and Anticatabolic Agents in Burns

摘要: Burn results in a substantial release of inflammatory mediators, which leads to significant metabolic derangements and the introduction post-injury stress environment, hypermetabolic response. This response is characterized by vast catabolism, if untreated, it physiological exhaustion, organ failure, even death. Particularly, an important feature post-burn generalized catabolism. Hypercatabolism can be attributed shift production anabolic catabolic factors. Increased levels proinflammatory cytokines occur immediately after injury are intimately associated with augmented hormones, principally cortisol catecholamines. Furthermore, hypermetabolism suppression endocrine axis, result decrease serum endogenous hormones. Indeed, burn patients exhibit diminished hormones such as human growth hormone (hGH), IGF-I, testosterone post-trauma. Non-pharmacologic interventions exercise, appropriate nutrition, heating environment have been employed manage post-trauma hypermetabolism. While they improve pharmacologic appear critical for clinical efficacy. Various pharmacological strategies used prevent catabolism promote anabolism thermally injured patients. chapter analyzes anticatabolic currently utilized. It will cover propranolol, (GH), insulin factor 1 (IGF-1), binding protein 3 (IGFBP-3), insulin, metformin, testosterone, oxandrolone, thyroid novel therapeutics utilized other conditions, cancer-related cachexia, discussed.