V(H) Gene Products Allow Specific Communication Among Immunologic Cell Sets

摘要: Stimulation of the immune system by foreign materials usually results in production antibody. The basis for regulation duration, intensity, and amount antibody is not well understood. first theories that made sense were based on demonstration Darwinian rules had been put to elegant experimental tests Luria Delbruck also applied system. These ideas fairly straightforward, keeping with what was known about at time: responses thought as a result relative concentrations antigen specific antibodies serum; complexing mask antigenic determinants gradually decrease effective concentration stimulation (see Uhr Moller, 1968). Additional analysis suggested antigen-antibody complexes might themselves inactivate antibody-secreting lymphocytes (or their immediate precursors) either altering molecular configuration (Diener Feldmann, 1972) or via direct effect Fc portion (Chan Sinclair, 1971; Murgitta Vas, 1972). In case, these models relied upon three basic elements: antibody, antigen, cell.