Oxidative Stress with Emphasis on the Role of LAMMA in Parkinson’s Disease

摘要: Until recently, the causes and underlying pathogenetic mechanisms responsible for cell degeneration in neurodegenerative disorders have remained obscure. Neuro-pathological analysis revealed presence of cytoskeletal markers such as Lewy body neurofibrillary tangle, which are associated with neuronal degeneration, but cellular events these changes were unknown. More it has been proposed that oxidative stress may be a unifying factor pathogenesis major diseases (Olanow, 1993). This hypothesis proposes an increase free radicals due to excess formation or diminished antioxidant defenses is damage critical biological molecules proteins, membrane lipids, DNA. chapter will review evidence contributes Parkinson’s disease (PD), particular emphasis on role laser microprobe mass (LAMMA) therapeutic implications observations.